The Australian-Canadian Prostate Cancer Research Alliance is a partly Queensland government-funded network of Australian and Canadian academic, scientific, and clinical experts and scholars working in the area of prostate cancer. We provide a framework to facilitate the advancement of discoveries, from high tech applications through to validation, preclinical proof of principle, and clinical evaluation. The primary hub of the AC-PCRA is led by the Australian Prostate Cancer Research Centre – Queensland, which is a collaboration between the Queensland University of Technology, and the Princess Alexandra Hospital in Brisbane, Australia. A major Canadian collaborator is the Vancouver Prostate Centre.